Longevity Medicine
What Supplements Support Healthy Aging?
Last reviewed: May 2026 · Haute MD Editorial Team
Supplements with the strongest evidence for healthy aging include omega-3 fatty acids (EPA/DHA), vitamin D3 with K2, magnesium, creatine monohydrate, and NMN or NR (NAD precursors). Focus on evidence-based supplements in high-quality formulations rather than taking dozens of poorly researched products.
Core evidence-based supplements
Omega-3 (EPA/DHA), vitamin D3 with K2, magnesium glycinate or threonate, creatine monohydrate (5 g/day), and NAD precursors (NMN or NR). These have the most robust supporting evidence for general healthy aging.
Selecting quality products
Look for third-party tested brands (NSF, USP, Informed Sport) and physician-recommended dosing. Avoid mega-doses without clinical rationale and avoid proprietary blends that obscure individual ingredient amounts.
Frequently Asked Questions
Should everyone take a multivitamin?
Most evidence does not support routine multivitamin use in well-nourished adults. Targeted supplementation based on lab work is more effective.
Is creatine just for athletes?
No. Creatine has strong evidence for muscle, cognitive, and bone health benefits at any age.
Do I need to take supplements forever?
Some (vitamin D, omega-3) are typically lifelong. Others are dosed based on lab values and may be cycled.
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