Twice As Nice: Experts Reveal The Best Aesthetic Treatment Pairings

When it comes to aesthetic treatments, the secret to flawless results often lies in the perfect combination. Pairing treatments—like neuromodulators with laser resurfacing or dermal fillers with collagen stimulators—can amplify benefits, enhance longevity, and create a more natural, refreshed look. So, we turned to our Haute Beauty experts and asked them to share their favorite treatment combinations and why they swear by these dynamic duos.

Aesthetic Island NYC | Medical Spa | Brooklyn, NY

At Aesthetic Island, one of our most powerful treatment combinations is Morpheus8 paired with Sculptra—a game-changing duo for skin tightening, collagen regeneration, and long-lasting facial rejuvenation.

Why does this combo work so well?

• Morpheus8 uses radiofrequency (RF) microneedling to tighten the skin, improve texture, and trigger collagen production deep within the dermis. It’s perfect for addressing fine lines, sagging, and uneven skin tone.
• Sculptra is a collagen-stimulating injectable that works over time to rebuild the skin’s structure, restoring volume and elasticity for a youthful, lifted look. Unlike traditional fillers, Sculptra enhances your skin’s natural ability to regenerate collagen.

Who is this for?
This treatment is ideal for clients experiencing mild to moderate skin laxity and looking for a non-surgical alternative to a facelift. It’s also great for those who want to maintain their results longer, as Sculptra keeps working beneath the surface for up to two years.

By combining these two powerhouse treatments, we tighten, firm, and restore lost volume, delivering both immediate improvement and long-term benefits. At Aesthetic Island, we customize every treatment plan to ensure natural, youthful, and long-lasting results.

For more information, visit Aesthetic Island NYC's website, Instagram, or Facebook!

Dr. Kiran Gill, Naples Aesthetic Institute | Body | Naples, FL

Combination treatments are indeed gaining popularity for their ability to enhance results and provide a more comprehensive approach to aesthetic care. One of my favorite pairings is Botox with dermal fillers. While Botox effectively relaxes dynamic wrinkles, fillers restore volume and contour to areas like the cheeks and lips, creating a balanced and youthful appearance.

Another powerful combination is laser treatments with collagen boosters. Laser therapies, such as fractional CO2 or IPL, can rejuvenate the skin by targeting pigmentation and texture issues. When paired with collagen boosters like Sculptra, we can stimulate collagen production, leading to long-lasting improvements in skin elasticity and firmness.

These combinations not only address multiple concerns simultaneously but also enhance the overall outcome, providing patients with a more refreshed and natural look. Always consult with a qualified professional to tailor these treatments to individual needs for optimal results.

For more information, visit the Naples Aesthetic Institute's website, Instagram, or Facebook!

Dr. Sarah Khan, ARA Med Spa | Medical Spa | Los Angeles, CA

Hydrafacial is an excellent non-invasive skin treatment that uses patented technology to cleanse, decongest, and hydrate the skin deeply. Aside from being customizable with personalized skin booster serums to target specific skin concerns and being scientifically proven to lead to clearer skin, it can also be nicely paired with lymphatic drainage and LED light therapy for optimum results.

Lymphatic facial massage can be performed in the same treatment setting with a hydrafacial. Lymphatic massage stimulates facial lymph nodes to increase blood flow, remove toxins, and decrease inflammation. The synergistic results from these two treatments include improvement in facial puffiness and swelling with gentle contouring.

LED light therapy can follow a hydrafacial treatment and can also be performed in the same treatment appointment. The individual benefits of LED light therapy are anti-aging effects, reduced inflammation, wound healing, and improved skin texture. LED light therapy is FDA-approved using our Lightstim Elipsa device and is customizable at two different wavelengths: red light is used to treat acne for 12 minutes, and blue light is used to treat acne for 16 minutes. The synergistic advantage of combining hydrafacial and LED light therapy allows deeper penetration into the skin with a radiant and glowing appearance.

For more information, visit ARA Med Spa's website, Instagram, or Facebook!

Heather Merlo, Sei Tu Bella Aesthetics | Medical Spa | Tampa, FL

Morpheus8 radio-frequency microneedling and exosomes have long been my go-to combination for skin rejuvenation, but I am seeing a growing interest in polynucleotide and peptide-based mesotherapy treatments with the world-renowned brand of TOSKANI. These advanced treatments deliver targeted nutrients to the skin, improving hydration, elasticity, and overall anti-aging and regenerative benefits. Gaining significant attention in the aesthetic industry, often referred to as the “salmon sperm facial”, features Sodium DNA (PDRN), a powerful polynucleotide that enhances cellular repair, deeply hydrates, and stimulates collagen synthesis for firmer, more resilient skin.

This non-surgical treatment involves mesotherapy delivery of a concentrated solution of polynucleotides (salmon DNA) directly into the skin. As the skin heals, these potent molecules deeply penetrate, promoting collagen production, improving elasticity, reducing fine lines, and combating oxidative stress, all while accelerating cellular regeneration. TOSKANI leads the way with the highest concentration of PDRN at 3% alongside a range of scientifically validated skincare solutions designed to target specific concerns and restore skin vitality. These advanced formulations enhance treatment outcomes and support overall skin health, making this an increasingly popular combination therapy at Sei Tu Bella Aesthetics in Tampa, Florida.

For more information, visit Sei Tu Bella Aesthetics' website, Instagram, or Facebook!

Dr. Jason Bloom | Face | Philadelphia

Combination treatments are really “trending” right now, and periorbital rejuvenation procedures are always better when done together. When I am performing periorbital rejuvenation surgery, especially of the lower eyelid areas, I explain that these treatments work in concert to provide the best results. With these types of surgeries, I usually go through the lower eyelids to remove the “puffiness” or “bags” that some patients have. When I conservatively remove this fat, it will have a nice effect on the contour of the lower eyelid areas. The important thing that I explain to patients is that this is not enough to get a good result by itself. I always perform volume restoration with structural fat grafting to the midface, infraorbital hollows, and sometimes temples to “future-proof” the eyes. The combination of adding fat grafting to lower eyelid blepharoplasty helps to smooth the lid-cheek junction, lateral orbital hollow, and midface. This prevents the patient from having a hollowed-out look. Finally, while these procedures in combination help to address the contours and volume status of the periorbital areas, they don’t help to improve the periocular skin wrinkling or texture. This is where fully or fractionated ablative laser resurfacing comes into play. Combining ablative laser resurfacing with these procedures really helps to improve the overall result in these cases.

For more information, visit Dr. Bloom's website, Instagram, or Facebook!

Iani Silveira, Bella Vida Aesthetics & Wellness | Medical Spa | Miami, FL

Botox and polynucleotides (PN) are becoming a popular combination for achieving more youthful, rejuvenated skin at Bella Vida Aesthetics and Wellness. Botox is known for relaxing the muscles that cause wrinkles, especially around the forehead, crow's feet, and between the brows. By temporarily paralyzing these muscles, Botox smooths out fine lines and wrinkles, creating a more youthful appearance.

Polynucleotides, such as PDRN (Polydeoxyribonucleotide), are a newer addition to aesthetic treatments. They are derived from salmon DNA and help to regenerate and repair skin at a cellular level. PN treatments have powerful skin-healing properties, promoting collagen production and enhancing skin hydration. When applied via injections, they can help with skin texture, elasticity, and overall skin health.

Combining Botox with polynucleotides can provide both immediate and long-term benefits. Botox smooths wrinkles right away, while polynucleotides work to stimulate skin regeneration and improve its quality over time. This combination is ideal for clients who want both anti-aging effects on muscle movement and skin renewal, leading to a more radiant and youthful look.

For more information, visit Bella Vida Aesthetics & Wellness's website, Instagram, or Facebook!

Dr. Husam Almunajed | Smile | New York, NY

In the pursuit of a perfect smile, combining Invisalign and porcelain veneers offers a powerful, minimally invasive solution. This dynamic duo addresses both functional and aesthetic concerns, delivering natural-looking, long-lasting results.

Invisalign, known for its clear, removable aligners, gently straightens teeth without the need for traditional braces. By correcting misalignment first, Invisalign minimizes the amount of tooth preparation required for veneers. This conservative approach preserves more of the natural tooth structure, enhancing long-term dental health.

Once teeth are properly aligned, porcelain veneers refine the smile by improving the shape, size, and color of the teeth. Veneers are thin, durable shells custom-crafted to deliver a flawless appearance. Since Invisalign has already corrected the tooth position, veneers can be applied with minimal enamel removal, ensuring a more conservative and sustainable outcome.

Together, these treatments complement each other perfectly. Invisalign lays the foundation for a healthy, aligned smile, while porcelain veneers add the finishing touch, correcting imperfections like discoloration, chips, and minor fractures. This combination not only achieves a stunning aesthetic result but also enhances durability and function.

For patients seeking a comprehensive smile makeover, the synergy between Invisalign and porcelain veneers provides a balanced, conservative, and long-lasting solution that transforms smiles with minimal shaping and interventions. The days of aggressive shaping of teeth and peg teeth are long gone.

For more information, visit Dr. Almunajed's website, Instagram, or Facebook!

Dr. Kian Karimi | Face | Los Angeles, CA

Combination treatments are the gold standard for achieving optimal skin rejuvenation, and one of my favorite pairings is BroadBand Light Therapy (BBL HEROic) with Moxi laser resurfacing, followed by a powerhouse blend of regenerative topicals and a CO2 Lift carboxytherapy mask.

BBL HEROic is the latest advancement in light-based technology, effectively targeting pigmentation, redness, and signs of aging by stimulating skin renewal at a cellular level. When paired with the Moxi laser, which focuses on improving skin texture, tone, and collagen production, we achieve a synergistic effect—refining the skin’s surface while simultaneously addressing deeper concerns like sun damage and fine lines.

To enhance healing and accelerate results, we immediately apply topical exosomes, which deliver over 250+ growth factors to boost collagen production and tissue repair. Next, Polydeoxyribonucleotide (PDRN), derived from salmon polynucleotide, supports the extracellular matrix, improving elasticity and luminosity. Cannabidiol (CBD), a potent anti-inflammatory and antioxidant, is then applied to regulate oil production, soothe irritation, and protect against environmental stressors.

We complete the protocol with the CO2 Lift carboxytherapy mask, which enhances oxygenation, boosts blood flow, and promotes collagen synthesis—ensuring that patients experience faster recovery and radiant, youthful skin. This multi-modal approach delivers unparalleled skin renewal with minimal downtime.

For more information, visit Dr. Karimi's website, Instagram, or Facebook!

Dr. Anna Chacon | Skin | Miami, FL

Combination treatments are an excellent way to enhance and prolong aesthetic results. One of my favorite pairings is Botox with laser resurfacing treatments. Botox helps relax dynamic wrinkles, while laser resurfacing improves skin texture, tone, and collagen production. Together, they provide a more youthful and refreshed appearance.

Another effective combination is dermal fillers with collagen-boosting treatments like Sculptra or biostimulators. Fillers restore lost volume and contour the face, while collagen boosters work over time to enhance skin firmness and elasticity. This approach ensures both immediate and long-term rejuvenation.

For patients looking to improve skin laxity, I often recommend radiofrequency microneedling paired with PRP (platelet-rich plasma). This combination stimulates collagen while promoting skin healing and regeneration for a firmer, smoother complexion.

For more information, visit Dr. Chacon's website, Instagram, or Facebook!

Dr. Oliver Chang | Brazilian Butt Lift | Miami, FL

Combination treatments are gaining popularity for their ability to address multiple skin concerns simultaneously, delivering more comprehensive and natural results, but finding the right pair for any individual requires an expert to give a full evaluation.

One effective pairing is Botox with microneedling or PRP. Botox smooths wrinkles, particularly in areas like the forehead and eyes, while microneedling or PRP helps stimulate collagen production, improving skin texture and tone. Microneedling also enhances Botox absorption, while PRP promotes skin rejuvenation.

Another popular combination is dermal fillers with radiofrequency (RF) treatments. Fillers restore volume and smooth out wrinkles, while RF treatments like Morpheus8 tighten the skin and stimulate collagen production, giving a more lifted and youthful appearance. Botox paired with laser resurfacing (such as Fraxel or CO2 lasers) is also a sought-after combo, addressing dynamic wrinkles with Botox while laser resurfacing improves skin texture, pigmentation, and stimulates collagen for a more overall rejuvenated look.

Additionally, fillers combined with collagen boosters like Sculptra or Radiesse can provide immediate volume restoration while also enhancing skin quality over time by stimulating collagen. A chemical peel paired with LED light therapy is another great combination, with the peel exfoliating and brightening the skin and LED light aiding in healing and stimulating collagen production.

Finally, the classic pairing of Botox with fillers targets both the upper and lower face to smooth wrinkles and restore volume, resulting in a balanced facial rejuvenation. But find an expert to make sure the right pairing is done for you.

For more information, visit Dr. Chang's website, Instagram, or Facebook!

Victoria A. Cirillo-Hyland, MD, FAAD | Skin | Philadelphia, PA

When it comes to combination treatments, Lutronic’s™ Genius™ Microneedling Radiofrequency Device and Lase MD™ Thulium Laser work together seamlessly to deliver superior skin rejuvenation. This TotalSkin Solution™ targets multiple layers of the skin, enhancing collagen production while improving texture and tone.

• Genius™ Microneedling Radiofrequency Device stimulates deep skin remodeling by delivering thermal energy through microneedles. This process tightens the skin and triggers long-term collagen production for a firmer, more youthful appearance.
• Lase MD™ Thulium Laser focuses on the skin’s surface, addressing fine lines, age spots, and uneven texture. By creating microchannels, it enhances the absorption of therapeutic serums, amplifying the skin’s overall radiance.

Together, these technologies provide a comprehensive approach to skin rejuvenation, making them a go-to pairing for those seeking both deep collagen remodeling and surface-level refinement.

For more information, visit Dr. Cirillo-Hyland's website, Instagram, or Facebook!

Fillir | Medical Spa | Pittsburgh, PA

At fillir, we love combination treatments because they allow us to target multiple concerns simultaneously—delivering faster, more comprehensive results for our clients.

By pairing complementary treatments, we’re able to boost the effectiveness of each. For example, combining Botox with Microneedling not only smooths fine lines but also improves skin texture and tone, creating a more radiant, youthful complexion. Combination treatments allow us to tailor your experience to meet your unique goals. Whether you're seeking volume restoration, wrinkle reduction, or skin rejuvenation, we can mix and match services like fillers, neurotoxins, and collagen boosters for a personalized treatment plan that works for you.

Here are some of our favorite duos trending right now:

• Tox + Microneedling – Smooth wrinkles while improving skin tone and texture. A perfect duo for a refreshed, youthful glow.
• Filler + Collagen Boosters (Sculptra)– Instant volume with filler + long-term collagen stimulation = the ultimate anti-aging boost
• Lip Filler + Lip Flip – A subtle enhancement for fuller-looking lips without adding too much volume
• VI Peel + Dermaplane –Dermaplaning preps the skin for deeper peel penetration, revealing a brighter, more even complexion.

Pairing treatments means better results, longer-lasting effects, and a customized approach to your skin goals.

For more information, visit Fillir's website, Instagram, or Facebook!

Dr. Daniel Careaga, Careaga Plastic Surgery | Body | Miami, FL

As a double board-certified plastic surgeon, I specialize in combination procedures that restore confidence and enhance natural beauty. The Mommy Makeover is one of the most transformative treatments, allowing women to reclaim their bodies with a single recovery period.

My favorite pairing? A tummy tuck with a breast lift and implants. This combination tightens the abdominal muscles, removes excess skin, and restores youthful breast shape and volume. It’s the perfect way to achieve a balanced, proportionate figure.

For patients who want a sculpted look but don't necessarily have loose skin, liposuction is an excellent alternative. By refining the abdomen, waist, flanks, and/or back, we enhance curves and define the silhouette for a more dramatic transformation.

By customizing each Mommy Makeover to my patients’ needs, I ensure they achieve natural-looking, long-lasting results that enhance their confidence and body harmony.

For more information, visit Careaga Plastic Surgery's website, Instagram, or Facebook!