111SKIN Launches First Exclusive US Spa/Clinic at The Plaza Hotel in New York City

Photo Credit: 111SKIN SPA/CLINIC

The world of luxury skincare has reached a new milestone with the grand opening of the 111SKIN Spa/Clinic at The Plaza Hotel in New York City. Marking the brand’s first exclusive spa location in the United States, this launch represents a seamless blend of clinical precision, innovative science, and the timeless glamour of one of Manhattan’s most iconic destinations. Situated at the legendary Plaza Hotel on Fifth Avenue and Central Park South, the new 111SKIN Spa/Clinic promises to redefine the way New Yorkers experience wellness and beauty.

Inspired by the brand’s origins at 111 Harley St. in London, the new 8,000-square-foot sanctuary combines high-performance treatments with indulgent rituals designed to deliver visible, long-lasting results. Every element of the space — from its serene treatment rooms to its private relaxation lounges — reflects 111SKIN’s commitment to modern elegance and holistic rejuvenation. Guests can immerse themselves in a curated environment where advanced technology meets the art of self-care, creating a truly transformative journey from start to finish.

Photo Credit: 111SKIN SPA/CLINIC

The 111SKIN Spa/Clinic introduces a menu of exclusive treatments that bring science to life through luxury. Each facial and body service is meticulously designed to target specific skin needs while promoting overall wellness. Among the most anticipated offerings is the Exosome Regenerative Facial, an innovative new treatment that uses microdermabrasion, ultrasonic cleansing, ultrasound, LED therapy, and advanced exosome technology to rejuvenate and repair the skin at a cellular level. The result is a visibly revitalized complexion with improved tone, texture, and radiance.

Alongside this groundbreaking facial, guests can experience some of 111SKIN’s most sought-after treatments, including the Reparative Longevity Facial, Black Diamond Non-Surgical Lift Facial, and Glass Skin Facial. Each service integrates scientifically developed skincare formulas with cutting-edge techniques to provide measurable results while maintaining a luxurious, relaxing experience. The brand’s approach bridges clinical innovation with sensory indulgence, ensuring that every visit leaves clients feeling both restored and radiant.

For 111SKIN co-founder Dr. Yannis Alexandrides, this expansion into New York City represents an important step in bringing his science-backed skincare philosophy to a wider audience. “It’s a huge privilege to call The Plaza Hotel our new home. As an extension of my practice at 111 Harley St., I couldn’t think of a more fitting establishment to bring our science-backed, luxurious skincare and experiences to New York,” he shared. His vision is to make advanced skincare treatments more accessible while maintaining the brand’s hallmark of sophistication and personalization.

Photo Credit: 111SKIN SPA/CLINIC

The Plaza Hotel’s Managing Director, Sam Ioannidis, expressed his enthusiasm for the partnership, stating, “By uniting innovation in longevity with our legacy of glamour, we’re redefining what wellness means at our property with the arrival of the 111SKIN Spa/Clinic.” This collaboration perfectly aligns with The Plaza’s long-standing reputation for offering world-class experiences that blend heritage with modern luxury.

The Plaza Hotel has been a global icon since its opening in 1907, welcoming generations of leaders, celebrities, and tastemakers from around the world. Its timeless architecture and historic charm have made it a symbol of prestige in New York City, appearing in countless films and serving as the backdrop for many of society’s most glamorous events. Today, The Plaza continues to evolve as a destination for refined living, offering guests not only luxurious accommodations but also an elevated lifestyle experience.

The arrival of 111SKIN at The Plaza underscores the growing demand for wellness spaces that offer more than just beauty treatments. Here, every service is rooted in science, with a focus on longevity, performance, and rejuvenation. By merging clinical-grade skincare innovations with bespoke service, the new 111SKIN Spa/Clinic sets a new benchmark for the luxury spa industry in New York.

Photo Credit: 111SKIN SPA/CLINIC

Guests visiting the spa can expect a fully personalized approach from consultation to completion, with expert therapists tailoring each treatment to meet individual skin needs. The result is an immersive escape that embodies 111SKIN’s philosophy: merging science and beauty in perfect harmony. For those seeking next-generation facials and results-driven skincare in an elegant setting, The Plaza Hotel now offers an experience that is both exclusive and unforgettable.

Located on the fourth floor of The Plaza at 768 Fifth Avenue in New York City, the 111SKIN Spa/Clinic invites both hotel guests and locals to discover the future of luxury skincare. Appointments can be made by calling 212.872.7200 or visiting www.111skinspa.com.