The 39-year-old Family Guy creator is being outfitted by Gucci for his big night.
The Hollywood Reporter overheard MacFarlane telling a friend about his fashion selection at HBO’s Golden Globes party.
It is possible, however, given his love of costuming, that he may change outfits many times during the ceremony.
Other fans of the brand include Javier Bardem, James Franco and Brad Pitt. Ben Affleck, Robert Pattinson and Ryan Gosling all wore Gucci to the Golden Globes last Sunday.